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Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.

Identifieur interne : 000152 ( Main/Exploration ); précédent : 000151; suivant : 000153

Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.

Auteurs : Filipe I. Daniel [Brésil] ; Soraia R. Alves [Brésil] ; Daniella S C. Vieira [Brésil] ; Michelle T. Biz [Brésil] ; Inah W B S. Daniel [Brésil] ; Filipe Modolo [Brésil]

Source :

RBID : pubmed:27159259

Descripteurs français

English descriptors

Abstract

BACKGROUND

Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this study was to investigate the immunoexpression of DNMTs 1, 3a, and 3b in lip precancerous lesion (actinic cheilitis) and cancer.

METHODS

Thirty cases of actinic cheilitis (AC), thirty cases of lip squamous cell carcinoma (LSCC), and twenty cases of non-neoplastic tissue (NNT) were selected for immunohistochemical investigation of DNMTs 1, 3a, and 3b.

RESULTS

Nuclear DNMT 1 immunoreactivity was significantly higher in the LSCC group (68.6%) compared with NNT (47%), and nuclear DNMT 3b was higher in LSCC (70.9%) than in NNT (37.9%) and in AC (44%). Only DNMT 3a showed both higher nuclear and cytoplasmic expression in AC (35.9% and 35.5%, respectively) than in NNT (4.4% and 16.1%, respectively) and LSCC (8.8% and 13.2%, respectively) (P < 0.05).

CONCLUSIONS

The results suggested that DNMT 3a could play a key role in the methylation process of initial steps of UV carcinogenesis present in AC while DNMT 3b could be responsible for de novo methylation in already established lip cancer.


DOI: 10.1111/jop.12453
PubMed: 27159259


Affiliations:


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<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Carcinogenesis (immunology)</term>
<term>Carcinogenesis (metabolism)</term>
<term>Carcinogenesis (pathology)</term>
<term>Carcinoma, Squamous Cell (enzymology)</term>
<term>Carcinoma, Squamous Cell (immunology)</term>
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<term>Cheilitis (enzymology)</term>
<term>Cheilitis (immunology)</term>
<term>Cheilitis (pathology)</term>
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<term>Child, Preschool (MeSH)</term>
<term>DNA (Cytosine-5-)-Methyltransferases (biosynthesis)</term>
<term>DNA (Cytosine-5-)-Methyltransferases (metabolism)</term>
<term>Female (MeSH)</term>
<term>Head and Neck Neoplasms (enzymology)</term>
<term>Head and Neck Neoplasms (immunology)</term>
<term>Head and Neck Neoplasms (pathology)</term>
<term>Humans (MeSH)</term>
<term>Immunohistochemistry (MeSH)</term>
<term>Lip Neoplasms (enzymology)</term>
<term>Lip Neoplasms (immunology)</term>
<term>Lip Neoplasms (pathology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Repressor Proteins (biosynthesis)</term>
<term>Repressor Proteins (metabolism)</term>
<term>Squamous Cell Carcinoma of Head and Neck (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Carcinogenèse (anatomopathologie)</term>
<term>Carcinogenèse (immunologie)</term>
<term>Carcinogenèse (métabolisme)</term>
<term>Carcinome épidermoïde (anatomopathologie)</term>
<term>Carcinome épidermoïde (enzymologie)</term>
<term>Carcinome épidermoïde (immunologie)</term>
<term>Carcinome épidermoïde de la tête et du cou (MeSH)</term>
<term>Chéilite (anatomopathologie)</term>
<term>Chéilite (enzymologie)</term>
<term>Chéilite (immunologie)</term>
<term>DNA (cytosine-5-)-methyltransferase (biosynthèse)</term>
<term>DNA (cytosine-5-)-methyltransferase (métabolisme)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunohistochimie (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Protéines de répression (biosynthèse)</term>
<term>Protéines de répression (métabolisme)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Tumeurs de la lèvre (anatomopathologie)</term>
<term>Tumeurs de la lèvre (enzymologie)</term>
<term>Tumeurs de la lèvre (immunologie)</term>
<term>Tumeurs de la tête et du cou (anatomopathologie)</term>
<term>Tumeurs de la tête et du cou (enzymologie)</term>
<term>Tumeurs de la tête et du cou (immunologie)</term>
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<term>DNA (Cytosine-5-)-Methyltransferases</term>
<term>Repressor Proteins</term>
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<term>Carcinogenèse</term>
<term>Carcinome épidermoïde</term>
<term>Chéilite</term>
<term>Tumeurs de la lèvre</term>
<term>Tumeurs de la tête et du cou</term>
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<term>DNA (cytosine-5-)-methyltransferase</term>
<term>Protéines de répression</term>
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<term>Carcinome épidermoïde</term>
<term>Chéilite</term>
<term>Tumeurs de la lèvre</term>
<term>Tumeurs de la tête et du cou</term>
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<term>Carcinoma, Squamous Cell</term>
<term>Cheilitis</term>
<term>Head and Neck Neoplasms</term>
<term>Lip Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Carcinogenèse</term>
<term>Carcinome épidermoïde</term>
<term>Chéilite</term>
<term>Tumeurs de la lèvre</term>
<term>Tumeurs de la tête et du cou</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Carcinogenesis</term>
<term>Carcinoma, Squamous Cell</term>
<term>Cheilitis</term>
<term>Head and Neck Neoplasms</term>
<term>Lip Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Carcinogenesis</term>
<term>DNA (Cytosine-5-)-Methyltransferases</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Carcinogenèse</term>
<term>DNA (cytosine-5-)-methyltransferase</term>
<term>Protéines de répression</term>
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<term>Carcinogenesis</term>
<term>Carcinoma, Squamous Cell</term>
<term>Cheilitis</term>
<term>Head and Neck Neoplasms</term>
<term>Lip Neoplasms</term>
</keywords>
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Squamous Cell Carcinoma of Head and Neck</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Carcinome épidermoïde de la tête et du cou</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<b>BACKGROUND</b>
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<p>Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this study was to investigate the immunoexpression of DNMTs 1, 3a, and 3b in lip precancerous lesion (actinic cheilitis) and cancer.</p>
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<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Thirty cases of actinic cheilitis (AC), thirty cases of lip squamous cell carcinoma (LSCC), and twenty cases of non-neoplastic tissue (NNT) were selected for immunohistochemical investigation of DNMTs 1, 3a, and 3b.</p>
</div>
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<p>
<b>RESULTS</b>
</p>
<p>Nuclear DNMT 1 immunoreactivity was significantly higher in the LSCC group (68.6%) compared with NNT (47%), and nuclear DNMT 3b was higher in LSCC (70.9%) than in NNT (37.9%) and in AC (44%). Only DNMT 3a showed both higher nuclear and cytoplasmic expression in AC (35.9% and 35.5%, respectively) than in NNT (4.4% and 16.1%, respectively) and LSCC (8.8% and 13.2%, respectively) (P < 0.05).</p>
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<p>
<b>CONCLUSIONS</b>
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<p>The results suggested that DNMT 3a could play a key role in the methylation process of initial steps of UV carcinogenesis present in AC while DNMT 3b could be responsible for de novo methylation in already established lip cancer.</p>
</div>
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<NameOfSubstance UI="C411744">DMAP1 protein, human</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012097">Repressor Proteins</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>EC 2.1.1.37</RegistryNumber>
<NameOfSubstance UI="D004248">DNA (Cytosine-5-)-Methyltransferases</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>EC 2.1.1.37</RegistryNumber>
<NameOfSubstance UI="C120395">DNA methyltransferase 3A</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>EC 2.1.1.37</RegistryNumber>
<NameOfSubstance UI="C120396">DNA methyltransferase 3B</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList>
<SupplMeshName Type="Disease" UI="C535669">Actinic cheilitis</SupplMeshName>
</SupplMeshList>
<CitationSubset>D</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D063646" MajorTopicYN="N">Carcinogenesis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002613" MajorTopicYN="N">Cheilitis</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004248" MajorTopicYN="N">DNA (Cytosine-5-)-Methyltransferases</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006258" MajorTopicYN="N">Head and Neck Neoplasms</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008048" MajorTopicYN="N">Lip Neoplasms</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012097" MajorTopicYN="N">Repressor Proteins</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000077195" MajorTopicYN="N">Squamous Cell Carcinoma of Head and Neck</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">DNA methylation</Keyword>
<Keyword MajorTopicYN="N">actinic cheilitis</Keyword>
<Keyword MajorTopicYN="N">lip cancer</Keyword>
<Keyword MajorTopicYN="N">methyltransferases</Keyword>
<Keyword MajorTopicYN="N">squamous cell carcinoma</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="accepted">
<Year>2016</Year>
<Month>04</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2016</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2017</Year>
<Month>7</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2016</Year>
<Month>5</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">27159259</ArticleId>
<ArticleId IdType="doi">10.1111/jop.12453</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Brésil</li>
</country>
<region>
<li>Santa Catarina</li>
</region>
</list>
<tree>
<country name="Brésil">
<region name="Santa Catarina">
<name sortKey="Daniel, Filipe I" sort="Daniel, Filipe I" uniqKey="Daniel F" first="Filipe I" last="Daniel">Filipe I. Daniel</name>
</region>
<name sortKey="Alves, Soraia R" sort="Alves, Soraia R" uniqKey="Alves S" first="Soraia R" last="Alves">Soraia R. Alves</name>
<name sortKey="Biz, Michelle T" sort="Biz, Michelle T" uniqKey="Biz M" first="Michelle T" last="Biz">Michelle T. Biz</name>
<name sortKey="Daniel, Inah W B S" sort="Daniel, Inah W B S" uniqKey="Daniel I" first="Inah W B S" last="Daniel">Inah W B S. Daniel</name>
<name sortKey="Modolo, Filipe" sort="Modolo, Filipe" uniqKey="Modolo F" first="Filipe" last="Modolo">Filipe Modolo</name>
<name sortKey="Vieira, Daniella S C" sort="Vieira, Daniella S C" uniqKey="Vieira D" first="Daniella S C" last="Vieira">Daniella S C. Vieira</name>
</country>
</tree>
</affiliations>
</record>

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